Career Opportunities

Partners HealthCare Center for Personalized Genetic Medicine (PCPGM) is a part of Partners HealthCare. Partners HealthCare, founded by Brigham and Women’s Hospital and Massachusetts General Hospital is one of the largest health care systems in the United States. Our hospitals are world-renowned for their contributions to the advancement of health care through patient care, research and teaching the next generation of physicians. Partners HealthCare comprises over 10 acute care and specialty hospitals, a physicians network, home care and many research facilities. We serve the health needs of the local community as well as those of patients from throughout the country and the world.

The Partners HealthCare Center for Personalized Genetic Medicine currently has exciting positions open for candidates. For position descriptions and to apply, please visit the Partners Careers page and search by job ID or career title. We look forward to hearing from you! The positions currently available at PCPGM are:

Clinical Laboratory Manager:
  • The PCPGM is seeking a Clinical Laboratory Manager to manage daily clinical laboratory operations at the Laboratory for Molecular Medicine.
  • To apply, search for Job ID# 2251546 on the Massachusetts General Hospital Careers website (www.massgeneral.org/careers)
Genetic Counselor:
  • The PCPGM is seeking a Genetic Counselor to serve as a liaison between PCPGM and outside clinicians.
  • To apply, search for Job ID# 2252911 on the Massachsetts General Hospital Careers website (www.massgeneral.org/careers)
Molecular Diagnostic Technician 2:
  • The PCPGM is seeking a mid-level Molecular Diagnostic Technician to perform routine clinical diagnostic testing in the Laboratory for Molecular Medicine.
  • To apply, search for Job ID# 2243828 on the Massachusetts General Hospital Careers website (www.massgeneral.org/careers/)
Senior Molecular Diagnostic Technician:
  • The PCPGM is seeking a senior-level Molecular Diagnostic Technician to organize and perform clinical diagnostic testing in the Laboratory for Molecular Medicine.
  • To apply, search for Job ID# 2246367 on the Massachusetts General Careers website (www.massgeneral.org/careers/)
Technical Research Assistant:
  • The PCPGM is seeking an entry level research assistant in the Translational Genomics Research Core to work with the latest technologies for high throughput genotyping, next generation sequencing and microarrays for gene expression.
  • To apply, search for Job ID# 2251446 on the Brigham and Women's Hospital Careers website (careers.brighamandwomens.org)

Clinical Laboratory Manager 

The mission of the Partners HealthCare Center for Personalized Genetic Medicine (PCPGM) is to utilize genetics and genomics to improve the care of patients through the promotion and implementation of personalized medicine in caring for patients throughout the Partners HealthCare System and in healthcare nationally and globally.

The Laboratory for Molecular Medicine (LMM) is a CLIA-certified clinical diagnostic laboratory operating within the center. The mission of the LMM is to bridge the gap between research and clinical medicine, translating novel discoveries into cutting-edge tests and accelerating the adoption of new molecular tests into clinical care. An integral component of the mission of the LMM is developing tests and tools on the latest technologies that facilitate the incorporation of genome and exome discoveries into everyday clinical care.

The successful candidate will perform as part of a clinical laboratory team under the direction of the Laboratory Directors in managing daily clinical lab operations. The candidate should demonstrate a proven ability to effectively manage staff and be able to assess and resolve problems as they arise—both administrative and technical. Working closely with the laboratory directors, implement measures to ensure appropriate quality control/quality assurance and quality improvement programs that comply with clinical regulatory agencies, eg CLIA, CAP, Joint Commission. Provide daily supervision and guidance to a skilled staff consisting of both senior and entry level technicians.

 

PRINCIPAL DUTIES AND RESPONSIBILITIES:

Successful candidate will promote the mission of the PCPGM and LMM to enable personalized medicine through the following tasks:

  • Functions as principal technical specialist for technologies including but not limited to next generation sequencing, Sanger sequencing, genotyping and other molecular technologies
  • Responsible for evaluating and improving laboratory workflows for next generation sequencing and other technologies introduced into clinical operations
  • Oversees the progress of clinical cases through the lab and troubleshoots difficult or atypical cases
  • Reviews compliance of written records of clinical assays and patient paperwork by technical staff.
  • Schedules and monitors laboratory experiments and analysis, modifies and communicates modifications to schedule as needed
  • Facilitates the training and competency assessments of technical staff, ensuring adequate coverage for all clinical testing.
  • Participates in quality control/quality assurance/quality improvement programs including but not limited to proficiency testing, staff competency programs, and identifying and improving assay performance issues, etc
  • Maintains proficiency on technically advanced procedures, as needed.
  • Contributes ideas and suggestions for improvements of existing standard operating procedures.
  • Creates and updates standard operating procedures and safety guidelines
  • Coordinate activities related to the lab’s infrastructure that are necessary to support the needs of an expanding clinical laboratory.
  • Assists with education of staff technicians and fellows and directs them on special projects.
  • Provides oversight and guidance for administrative duties such as accessioning and regulatory paperwork.
  • Oversees equipment maintenance and records, and facilitates troubleshooting and repairs of equipment and instruments
  • Monitors reagent and supply usage and coordinates ordering of supplies and general maintenance of the laboratory.
  • Forecasts supply/equipment budgets to monitor spending in these areas, and provides cost analysis for various procedures.
  • Leads weekly lab meetings geared towards the education of technicians, including coordinating talks by other staff members
  • Participates in the preparation of data for presentation and publication.

QUALIFICATIONS:

  • BS or MS in biology, genetics, molecular biology, or biochemistry or related field and at least 5 years experience in a clinical lab, either in a biotech or academic environment, with a minimum of 2 years management experience.

SKILLS/ ABILITIES/ COMPETENCIES REQUIRED:

  • Overall proficiency in molecular biology techniques–such as DNA extraction, gel electrophoresis, PCR, DNA sequencing (Sanger and next generation techniques), genotyping, microarray technologies, etc.
  • Proficiency in next generation sequencing technologies preferred
  • Ability to work in both a team and independently
  • Ability to function well in stressful situations and under time constraints
  • Must be able to logically and effectively structure tasks and set priorities for self and others
  • Dependability and excellent work habits
  • Multitasking abilities essential
  • Flexibility and adaptability to a changing environment
  • Must be able to make independent, effective decisions in appropriate situations.
  • Strong analytical and organizational skills
  • Aptitude for technical problem solving.
  • Ability to identify potential problems and troubleshoot solutions.
  • Motivated and able to master new techniques.
  • Good English oral and written communication skills.
  • Proven ability to work well with others in a team environment
  • Must have sound interpersonal skills and the ability to train and oversee others
  • High degree of computer literacy including, experience using Microsoft Office suite
  • Capable of multi-tasking and prioritizing efficiently while meeting deadlines
  • Demonstrate flexibility to adjust schedule in accordance with the needs of the department.
  • The ability to constructively interact with members of a team to pursue scientific goals is a necessity.

 

WORKING CONDITIONS:

  • Duties will be performed in a clinical laboratory. No direct patient contact will occur or be expected in the future.
  • Work will be conducted over a forty-hour work week, but actual schedule can be flexible.

SUPERVISORY RESPONSIBILITY:

  • Interviews prospective candidates, assesses job performance of technical personnel, and observes behavior requiring corrective discipline. Takes appropriate action (s) within guidelines and brings to attention of Laboratory Director.
  • Supervision and teaching of other technical staff (~10-15 positions of varying levels of experience)

Genetic Counselor

Under supervision of and in close consultation with the Director of Genetic Counseling and Molecular Geneticists, serve as a liaison between the Partners Laboratory for Molecular Medicine and outside clinicians. Interpret test results, draft reports and communicate test results to ordering physicians. Refer to appropriate specialists for additional genetics services, when applicable. Assist with new test development, collaborate on publications, generate marketing materials, update documents and text for the website, and occasionally represent the LMM at conferences. Possible option to provide some direct patient genetic counseling services in hospital-affiliated clinics.

PRINCIPAL DUTIES AND RESPONSIBILITIES

  1. Unique knowledge base: Become an expert in the clinical information of certain disease areas, develop an in-depth understanding of the molecular aspects of human diseases, develop a knowledge of testing technologies used in the laboratory and teach other physicians/genetic counselors in the field about these concepts through a variety of communication styles (i.e. written, oral, visual)
  2. Patient reporting: Design/maintain reporting templates, draft test interpretations, QC results in terms of clinical implications as well as any discrepancies between the clinical and molecular findings.
  3. Novel Variant/Gene Assessments: Research significance of variants and literature review
  4. Provide counseling services as needed: Answer emails and phone calls regarding our testing services, communication and interpretation of test results, risk assessment
  5. Interact with clinicians and hospitals: Develop close relationships with our clients to increase customer loyalty and satisfaction, act as an advocate for the needs and interests of physicians and patients in laboratory decisions, help address questions referred from the administrative staff, answer phone calls and emails regarding LMM, testing, and related issues
  6. PCPGM educational activities: Provide education to lab staff about clinical genetics/genetic counseling as needed, participate in genetic or disease related conferences through representing the LMM/PCPGM or speaking on behalf of the laboratory to share our data or testing technologies, supervise genetic counseling students during observations/rotations
  7. Development and maintenance of the LMM website: Write patient and physician information and update as necessary, generate required forms (info sheet, consent, requisition, insurance approval letters)

QUALIFICATIONS

M.S. from a program accredited by the American Board of Genetic Counseling. Board certified or board eligible by the American Board of Genetic Counseling.

SKILLS AND ABILITIES REQUIRED

  1. Meticulous organizational and managerial skills.
  2. Independence, initiative, creativity and problem-solving ability.
  3. Ability to interact effectively with large user base clinicians and patients.
  4. Desire to learn complex molecular genetics

WORKING CONDITIONS

Clinical molecular genetic diagnostic laboratory, Full time hours.


 Molecular Diagnostic Technician 2

The clinical lab technician will organize and perform routine laboratory tests including but not limited to:

 

Principal Duties and Responsibilities:

  • Extract and quantify DNA from blood and other tissue samples.
  • Perform gel electrophoresis and other techniques to analyze DNA and RNA products.
  • Perform PCR and DNA sequencing reactions.
  • Use robotics to perform repetitive laboratory techniques.
  • Learn how to use new instruments and implement their use in new tests.
  • Participate in lab meetings and generate ideas for improving efficiency and productivity in the lab’s operations.
  • Optimize diagnostic tests and update existing standard operating protocols with general guidance.
  • Follow existing protocols and regulations to QC equipment and reagents.
  • Enter requisition information and other report related data into a computer system.
  • Independently troubleshoot abnormal results with general guidance and feedback from senior laboratory members.
  • Train technicians on existing platforms.
  • Independently run new technologies with minimal supervision (after adequate training).
  • Act as a liaison with other laboratories and scientific cores.
  • Give general technical guidance to other members of the lab.
  • Communicates basic lab needs to Lab Manager for both technical and administrative issues.

Qualifications:

  • Bachelor’s degree in Biology, biochemistry, biotechnology, genetics or related field. Requires a minimum of one year experience, but in most cases 2+ years of molecular laboratory experience.

 

Senior Molecular Diagnostic Technician

 

The Senior Molecular Diagnostic Technician organizes and performs routine tests, while providing general direction and guidance to other lab technicians.

 Job Duties and Responsibilities:

  • Extract and quantify DNA from blood and other tissue samples.
  • Perform gel electrophoresis and other techniques to analyze DNA and RNA products.
  • Perform PCR and DNA sequencing reactions.
  • Use robotics to perform repetitive laboratory techniques.
  • Learn how to use new instruments and implement their use in new tests.
  • Participate in lab meetings and generate ideas for improving efficiency and productivity in the lab’s operations.
  • Manages and organizes laboratory projects.
  • Create and update standard operating protocols.
  • Follow existing protocols and regulations to QC equipment and reagents.
  • Enter requisition information and other report related data into a computer system.
  • Independently troubleshoot abnormal results with minimal oversight and feedback.
  • Train technicians on existing platforms.
  • Mentor entry-level technicians.
  • Implement new infrastructures to the lab, including new technologies and platforms.
  • Act as liaison with other laboratories and scientific cores.
  • Give general technical guidance to other members of lab.
  • Communicates basic lab needs to Lab Manager for both technical and administrative issues.
  • Responsible for organizing and maintaining laboratory inventory.
  • Serve as lab Fire Safety Officer and Chemical Safety Officer.
  • Oversees the progress of clinical cases through the lab and troubleshoots difficult or atypical cases.
  • Participates in quality control/ quality assurance/ quality improvement programs including but not limited to: Proficiency testing, identifying and Improving assay problems, maintaining log of atypical cases, etc.

Qualifications:  Bachelor’s degree in Biology, biochemistry, biotechnology, genetics or related science field.Requires 4+ years of molecular laboratory experience. Masters degree in biology, biochemistry, biotechnology, genetics, or related science field is a plus.


Technical Research Assistant

The Partners HealthCare Center for Personalized Genetic Medicine (PCPGM) is recruiting persons to join our high performing multidisciplinary team supporting genomics research for Partners investigators. Our team also works closely with the PCPGM Laboratory for Molecular Medicine supporting clinical genomics testing.

PRINCIPAL DUTIES AND RESPONSIBILITIES:
This is a full-time position reporting to the laboratory manager and Director of the Translational Genomics Core. Experience in biochemistry or molecular biology are expected. After training, the successful candidate will be working with the latest technologies for high throughput genotyping, next generation sequencing and Microarrays for Gene Expression. The individual will be responsible for but not limited to preparing and characterizing RNA and DNA samples for genotyping, gene expression or next-generation sequencing and for operating the instrumentation. Responsibilities will also include coordination with the lab manager on sample inventory needs, data entry, and general laboratory and instrument maintenance.

  1. Working under the supervision of senior research assistant and laboratory manager, the successful applicant will perform a variety of routine procedures following established methodologies. Routine procedures and duties will include but are not limited to: High throughput genotyping,  Next generation sequencing, Expression array processing
  2. With supervision, operates requisite laboratory equipment, instruments and robotics to perform repetitive laboratory techniques, Learns how to use new instruments and implement their use in new tests
  3. Performs with strong attention to detail and has ability to focus and perform tasks accurately and reproducibly
  4. Uses universal safety precautions and proper personal protective equipment to protect self and co-workers from biohazardous materials, including blood-borne pathogens
  5. Complies with biohazard/radiation safety standards through proper handling of potentially hazardous chemical and biological agents and/or radiation sources in the workplace
  6. Completes annual biohazard/universal precaution safety training, as appropriate.
  7. Records data; maintains and makes minor adjustments to equipment under supervision
  8. Participate in lab meetings and generate ideas for improving efficiency and productivity in the lab’s operations
  9. Communicate effectively with the team, discuss progress, and share data with supervisors
  10. All other duties as assigned

 

QUALIFICATIONS:
Bachelor's degree in life sciences, biochemistry, or chemistry with at least 1-2 years of experience in a laboratory setting required. Strong work ethic, attention to detail, and excellent organizational, documentation, and communication skills are essential requirements for this position. Good computer skills with excel and previous experience with liquid handling automation or sequencing methods are a plus.

SKILLS/ABILITIES/COMPETENCIES REQUIRED:

  1. Good organizational skills, detail oriented
  2. Reproducibility of work with accuracy
  3. Sound degree of computer literacy
  4. Ability to methodically record data
  5. Good interpersonal and communication skills
  6. Ability to demonstrate professionalism
  7. Dedication to excellence

Research Technician

The successful candidate will perform as part of a laboratory team supporting human subject studies at the Central Bio-repository for the Partners Biobank. The candidate should be comfortable handling samples of human origin in a laboratory setting, demonstrate a high attention to detail, and an ability to learn in a fast past setting. Duties include but are not limited to, routine performance of DNA and RNA extractions from various specimen types. The department is responsible for all receipt, processing, storage and shipping of research specimens for all users of the Partners Biobank as well as the specimen handling for the Laboratory for Molecular Medicine, a clinical diagnostic laboratory within PCPGM. The technician will be expected to be knowledgeable and comply with all Partners patient privacy guidelines.

PRINCIPAL DUTIES AND RESPONSIBILITIES:
Successful candidate will promote the mission of the PCPGM to enable personalized medicine through the following tasks:

  1. Working under the supervision of senior research assistant the successful applicant will perform a variety of routine procedures following established methodologies. Routine procedures and duties will include but are not limited to: DNA Extraction, RNA Extraction, Cell Transformation
  2. Maintains proficiency in all laboratory processes for central repository
  3. With supervision, operates requisite laboratory equipment, instruments and robotics to perform repetitive laboratory techniques
  4. Assists collecting and analyzing data for quality assurance and quality control programs
  5. Become expert on internal laboratory information management systems (LIMSs)
  6. Performs and maintains accurate records of equipment maintenance and quality control.
  7. Monitor preventative maintenance and schedules for automated extraction equipment, liquid handler(s), pipette calibrations and other supporting equipment.
  8. Assist with revising and updating protocols for the central repository
  9. Maintains safety. Practices safe work habits and directs staff as needed.
  10. Compliance with all laboratory regulations, including Joint Commission, CAP and other regulatory agencies
  11. Complies with biohazard/radiation safety standards through proper handling of potentially hazardous chemical and biological agents and/or radiation sources in the workplace.
  12. Uses universal safety precautions and proper personal protective equipment to protect self and co-workers from bio-hazardous materials, including blood-borne pathogens.
  13. Completes annual biohazard/universal precaution safety training, as appropriate.
  14. All other duties as assigned

QUALIFICATIONS:

  1. Bachelor’s degree in biology, biochemistry, biotechnology, genetics or related science field.
  2. Experience in molecular laboratory and/or a directly related research setting not required but will be considered favorably.
  3. Prior experience with DNA extraction or cell lines not required but will be considered favorably.
  4. Must be well-versed in laboratory standards and practices
  5. Must have US citizenship or appropriate visa/work status for the US


SKILLS/ ABILITIES/ COMPETENCIES REQUIRED:

  1. Strong analytical and organizational skills
  2. Aptitude for technical problem solving.
  3. Ability to identify potential problems and troubleshoot solutions.
  4. Motivated and able to master new techniques.
  5. Demonstrated ability to work independently.
  6. Good English oral and written communication skills.
  7. Proven ability to work well with others in a team environment
  8. Must have sound interpersonal skills
  9. High degree of computer literacy including, experience using Microsoft Office suite
  10. Demonstrate flexibility to adjust schedule in accordance with the needs of the department.
  11. The ability to constructively interact with members of a team to pursue scientific goals is a necessity.